Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC053
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-10-04 08:38
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment OLD PATIENT TBL MADOPAR 4X1\2 CAPS MADOPAR HBS 1X1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.67 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.67 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 5, 'TN': 5, 'TP': 37, 'FP': 25}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 16, 'TN': 11, 'TP': 26, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 23, 'TN': 15, 'TP': 19, 'FP': 15}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 12.548
timePerCircleCoV 0.192143
timePerCircleSlope 0.00268545
meanError 1.05878
tremorFreq 6.64062
tremorRelPower 36.4639
tremorGyroAmpMean 0.0123521
tremorGyroAmpSlope -0.00292028
tremorGyroAmpCoV 0.413718
tremorCoordAmpMean 0.0424524
tremorCoordAmpSlope -0.00175172
tremorCoordAmpCoV 0.387069
tremorAccAmpMean 0.0331237
tremorAccAmpSlope -0.00209698
tremorAccAmpCoV 0.395869
tremorPcRelVar 0.721813
tremorPcX -0.561745
tremorPcY 0.82731

Circle Segment 1

Duration 13.76 s, Accuracy Estimate 1.157 (lower is better)

Circle Segment 2

Duration 11.0 s, Accuracy Estimate 1.036 (lower is better)

Circle Segment 3

Duration 10.16 s, Accuracy Estimate 1.074 (lower is better)

Circle Segment 4

Duration 10.44 s, Accuracy Estimate 1.021 (lower is better)

Circle Segment 5

Duration 12.96 s, Accuracy Estimate 0.867 (lower is better)

Circle Segment 6

Duration 16.64 s, Accuracy Estimate 0.666 (lower is better)

Circle Segment 7

Duration 14.24 s, Accuracy Estimate 0.937 (lower is better)

Circle Segment 8

Duration 14.8 s, Accuracy Estimate 1.002 (lower is better)

Circle Segment 9

Duration 12.6 s, Accuracy Estimate 0.875 (lower is better)

Circle Segment 10

Duration 8.88 s, Accuracy Estimate 1.954 (lower is better)

Spiral

numSpirals 7
timePerSpiralMean 37.0457
timePerSpiralCoV 0.122263
timePerSpiralSlope -0.0200139
meanError 1.75999
tremorFreq 6.64062
tremorRelPower 43.084
tremorGyroAmpMean 0.0119121
tremorGyroAmpSlope 0.000953616
tremorGyroAmpCoV 0.385581
tremorCoordAmpMean 0.151571
tremorCoordAmpSlope 0.00662089
tremorCoordAmpCoV 1.48552
tremorAccAmpMean 0.029365
tremorAccAmpSlope 0.00103298
tremorAccAmpCoV 0.382011
tremorPcRelVar 0.608405
tremorPcX -0.134809
tremorPcY -0.990872

Spiral Segment 1

Duration 41.68 s, Accuracy Estimate 1.327 (lower is better)

Spiral Segment 2

Duration 39.76 s, Accuracy Estimate 1.654 (lower is better)

Spiral Segment 3

Duration 32.88 s, Accuracy Estimate 2.228 (lower is better)

Spiral Segment 4

Duration 33.8 s, Accuracy Estimate 1.63 (lower is better)

Spiral Segment 5

Duration 37.04 s, Accuracy Estimate 1.484 (lower is better)

Spiral Segment 6

Duration 42.84 s, Accuracy Estimate 1.609 (lower is better)

Spiral Segment 7

Duration 31.32 s, Accuracy Estimate 2.388 (lower is better)

Elel

eDurationMean 0.431585
eDurationStd 0.110648
eDurationStdnorm 0.256376
eDurationMedian 0.4
eDurationQuartdelta 0.1425
eDurationQuartdeltanorm 0.35625
eDurationKurt 5.31094
eDurationTrenddiff -0.055
eDurationTrendratio 0.871345
eWidthMean 4.66573
eWidthStd 1.35139
eWidthStdnorm 0.289641
eWidthMedian 4.797
eWidthQuartdelta 1.4625
eWidthQuartdeltanorm 0.304878
eWidthKurt 3.24556
eWidthTrenddiff -0.9945
eWidthTrendratio 0.8
eHeightMean 7.66778
eHeightStd 2.43505
eHeightStdnorm 0.317569
eHeightMedian 7.02
eHeightQuartdelta 3.77325
eHeightQuartdeltanorm 0.5375
eHeightKurt 2.38559
eHeightTrenddiff -0.702
eHeightTrendratio 0.904762
eAspectMean 0.640919
eAspectStd 0.191588
eAspectStdnorm 0.298927
eAspectMedian 0.644068
eAspectQuartdelta 0.235887
eAspectQuartdeltanorm 0.366245
eAspectKurt 2.71526
eAspectTrenddiff -0.119656
eAspectTrendratio 0.820083
eSlantMean 0.0707353
eSlantStd 0.155428
eSlantStdnorm 2.19731
eSlantMedian 0.0588235
eSlantQuartdelta 0.257097
eSlantQuartdeltanorm 4.37064
eSlantKurt 1.94251
eSlantTrenddiff -0.0997013
eRtopMean 0.769909
eRtopStd 0.0991736
eRtopStdnorm 0.128812
eRtopMedian 0.793103
eRtopQuartdelta 0.148939
eRtopQuartdeltanorm 0.187793
eRtopKurt 2.54144
eRtopTrenddiff -0.0678723
eRbotMean 0.678845
eRbotStd 0.279782
eRbotStdnorm 0.412144
eRbotMedian 0.642857
eRbotQuartdelta 0.251688
eRbotQuartdeltanorm 0.391515
eRbotKurt 10.7965
eRbotTrenddiff 0.117699
eRrightMean 0.862631
eRrightStd 0.0893285
eRrightStdnorm 0.103553
eRrightMedian 0.892308
eRrightQuartdelta 0.131728
eRrightQuartdeltanorm 0.147626
eRrightKurt 2.14875
eRrightTrenddiff -0.0460111
eRleftMean 0.335863
eRleftStd 0.107787
eRleftStdnorm 0.320925
eRleftMedian 0.324324
eRleftQuartdelta 0.122228
eRleftQuartdeltanorm 0.376868
eRleftKurt 5.04098
eRleftTrenddiff -0.0281226
lDurationMean 0.604878
lDurationStd 0.107299
lDurationStdnorm 0.17739
lDurationMedian 0.6
lDurationQuartdelta 0.1075
lDurationQuartdeltanorm 0.179167
lDurationKurt 3.67167
lDurationTrenddiff -0.0775
lDurationTrendratio 0.875502
lWidthMean 8.25849
lWidthStd 2.27579
lWidthStdnorm 0.27557
lWidthMedian 8.541
lWidthQuartdelta 3.18825
lWidthQuartdeltanorm 0.373288
lWidthKurt 3.4003
lWidthTrenddiff -0.819
lWidthTrendratio 0.905405
lHeightMean 23.4457
lHeightStd 2.8159
lHeightStdnorm 0.120103
lHeightMedian 23.283
lHeightQuartdelta 3.9195
lHeightQuartdeltanorm 0.168342
lHeightKurt 2.47027
lHeightTrenddiff -0.351
lHeightTrendratio 0.985037
lAspectMean 0.350842
lAspectStd 0.081805
lAspectStdnorm 0.233167
lAspectMedian 0.343874
lAspectQuartdelta 0.0941903
lAspectQuartdeltanorm 0.27391
lAspectKurt 3.39873
lAspectTrenddiff -0.039586
lAspectTrendratio 0.894345
lSlantMean 0.198579
lSlantStd 0.0866888
lSlantStdnorm 0.436546
lSlantMedian 0.199134
lSlantQuartdelta 0.0925328
lSlantQuartdeltanorm 0.464676
lSlantKurt 2.95445
lSlantTrenddiff -0.021601
lRtopMean 0.877625
lRtopStd 0.0578722
lRtopStdnorm 0.0659418
lRtopMedian 0.87
lRtopQuartdelta 0.0994691
lRtopQuartdeltanorm 0.114332
lRtopKurt 2.69799
lRtopTrenddiff 0.0585119
lRbotMean 0.338258
lRbotStd 0.139772
lRbotStdnorm 0.413211
lRbotMedian 0.31746
lRbotQuartdelta 0.133406
lRbotQuartdeltanorm 0.420229
lRbotKurt 4.13777
lRbotTrenddiff 0.0354397
lRrightMean 0.939182
lRrightStd 0.0337073
lRrightStdnorm 0.0358901
lRrightMedian 0.943005
lRrightQuartdelta 0.0367149
lRrightQuartdeltanorm 0.0389339
lRrightKurt 2.81005
lRrightTrenddiff 0.0102248
lRleftMean 0.208345
lRleftStd 0.112638
lRleftStdnorm 0.54063
lRleftMedian 0.186528
lRleftQuartdelta 0.110352
lRleftQuartdeltanorm 0.591609
lRleftKurt 5.32261
lRleftTrenddiff 0.0327568

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.918804
sumTouchScores 15.6197
meanMovementTime 1.04906
numTouches 17
undershootPercentage 0
overshootPercentage 11.7647

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.995115
sumTouchScores 9.95115
meanMovementTime 1.77222
numTouches 10
undershootPercentage 0
overshootPercentage 0

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 34.784
timePerZigzagCoV 0.109257
timePerZigzagSlope -0.0542778
meanError 2.08019
tremorFreq 6.54297
tremorRelPower 38.9868
tremorGyroAmpMean 0.0143522
tremorGyroAmpSlope 0.00127999
tremorGyroAmpCoV 0.428089
tremorCoordAmpMean 0.0612172
tremorCoordAmpSlope 0.00442335
tremorCoordAmpCoV 0.718598
tremorAccAmpMean 0.0327997
tremorAccAmpSlope 0.000888258
tremorAccAmpCoV 0.381295
tremorPcRelVar 0.823849
tremorPcX 0.13079
tremorPcY 0.99141

ZigZag Segment 1

Duration 41.32 s, Accuracy Estimate 1.975 (lower is better)

ZigZag Segment 2

Duration 33.16 s, Accuracy Estimate 1.956 (lower is better)

ZigZag Segment 3

Duration 33.96 s, Accuracy Estimate 1.959 (lower is better)

ZigZag Segment 4

Duration 34.04 s, Accuracy Estimate 2.031 (lower is better)

ZigZag Segment 5

Duration 31.44 s, Accuracy Estimate 2.479 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 14.16
timePerZigzagCoV 0.201428
timePerZigzagSlope -0.10226
zigzagHeightMean 46.3429
zigzagHeightCoV 0.0819854
zigzagHeightSlope -0.0457297
meanError 0.0417568
tremorFreq 6.15234
tremorRelPower 41.0803
tremorGyroAmpMean 0.0295499
tremorGyroAmpSlope 0.00833033
tremorGyroAmpCoV 0.358822
tremorCoordAmpMean 0.0954635
tremorCoordAmpSlope 0.015401
tremorCoordAmpCoV 1.01894
tremorAccAmpMean 0.0938763
tremorAccAmpSlope 0.00307407
tremorAccAmpCoV 0.178134
tremorPcRelVar 0.799302
tremorPcX 0.163894
tremorPcY 0.986478

ZigZag Offset Segment 1

Duration 19.2 s, Accuracy Estimate 0.044 (lower is better)

ZigZag Offset Segment 2

Duration 13.4 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 3

Duration 13.28 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 4

Duration 12.52 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 5

Duration 12.4 s, Accuracy Estimate 0.066 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.27}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.67}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.13468122478813838}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.7796695744322399}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}